Lipid Nanoparticles Carrying Essential Oils for Multiple Applications as Antimicrobials.

IF 5.5 3区医学 Q1 PHARMACOLOGY & PHARMACY Pharmaceutics Pub Date : 2025-01-31 DOI:10.3390/pharmaceutics17020178

Elenice Francisco da Silva, Fernanda Aparecida Longato Dos Santos, Henrique Machado Pires, Luciana Machado Bastos, Lígia Nunes de Morais Ribeiro

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Abstract

Lipid nanoparticles (LNPs) are versatile delivery systems with high interest because they allow the release of hydrophobic and hydrophilic molecules, such as essential oils (EOs) and plant extracts. This review covers published works between 2019 and 2024 that have reported the use of essential EO-based LNPs with antimicrobial properties and applications in human and animal health, as well as biopesticides. In the human healthcare field, reports have addressed the effect of encapsulating EOs in lipid nanosystems with antiviral, antibacterial, antiprotozoal and antifungal activities. In animal care, this still needs to be more deeply explored while looking for more sustainable alternatives against different types of parasites that affect animal health. Overall, the antibacterial activities of LNPs carrying EOs are described as alternatives to the use of synthetic antibiotics. In the field of agriculture, studies showed that these approaches in the control of phytopathogens and other pests that affect food production. There is a growing demand for innovative and more sustainable technologies. However, there are still some challenges to be overcome in order to allow these innovations to reach the market.

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脂质纳米颗粒携带精油作为抗菌剂的多种应用。

脂质纳米颗粒（LNPs）是一种多功能的递送系统，因为它们允许释放疏水和亲水分子，如精油（EOs）和植物提取物。本综述涵盖了2019年至2024年间发表的关于具有抗菌特性的基本eo基LNPs的使用及其在人类和动物健康以及生物农药中的应用的研究。在人类医疗保健领域，有报道称将EOs包埋在脂质纳米系统中具有抗病毒、抗菌、抗原虫和抗真菌活性。在动物护理方面，这仍需要更深入地探索，同时寻找针对影响动物健康的不同类型寄生虫的更可持续的替代方案。总的来说，携带EOs的LNPs的抗菌活性被描述为使用合成抗生素的替代品。在农业领域，研究表明，这些方法在控制影响粮食生产的植物病原体和其他害虫方面效果显著。对创新和更可持续的技术的需求日益增长。然而，为了让这些创新进入市场，仍有一些挑战需要克服。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.90

自引率

11.10%

发文量

2379

审稿时长

16.41 days

期刊介绍： Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications, and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.