Long He, Yi Li, Chonghua Zhang, Xingxing Zhang, Benhua Wang, Tianbing Ren, Lin Yuan
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引用次数: 0
Abstract
Small-molecule photothermal agents (PTAs) working in second near-infrared (NIR-II) region exhibited a great potential of cancer treatment and diagnosis for the advantages of minimal side effect, deeper penetration ability of tissue, and easily adjustable of structure. Various small-molecule PTA that integrate NIR-II fluorescence/photoacoustic (PA) imaging and thermal effect can visualize tumor locations and thermally irradiate tumor in real time, holding significant potential for early diagnosis and precision treatment of cancer. In this review, we summarize various strategies to improve the photothermal therapy (PTT) effects of small-molecule PTAs for NIR-II imaging-guided cancer treatment, including the enhancement of photothermal conversion efficiency (PCE) and photostability, the improvement of biocompatibility and specificity, and the facilitation of PTT by synergistic therapy. The perspectives and obstacles associated with NIR-II small-molecule PTAs for application are also discussed.
期刊介绍：
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.
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