Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR Coordination Chemistry Reviews Pub Date : 2025-06-15 Epub Date: 2025-02-27 DOI:10.1016/j.ccr.2025.216549

Long He , Yi Li , Chonghua Zhang , Xingxing Zhang , Benhua Wang , Tianbing Ren , Lin Yuan

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Abstract

Small-molecule photothermal agents (PTAs) working in second near-infrared (NIR-II) region exhibited a great potential of cancer treatment and diagnosis for the advantages of minimal side effect, deeper penetration ability of tissue, and easily adjustable of structure. Various small-molecule PTA that integrate NIR-II fluorescence/photoacoustic (PA) imaging and thermal effect can visualize tumor locations and thermally irradiate tumor in real time, holding significant potential for early diagnosis and precision treatment of cancer. In this review, we summarize various strategies to improve the photothermal therapy (PTT) effects of small-molecule PTAs for NIR-II imaging-guided cancer treatment, including the enhancement of photothermal conversion efficiency (PCE) and photostability, the improvement of biocompatibility and specificity, and the facilitation of PTT by synergistic therapy. The perspectives and obstacles associated with NIR-II small-molecule PTAs for application are also discussed.

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图像引导肿瘤治疗小分子NIR-II光热剂的研制

作用于第二近红外（NIR-II）区的小分子光热剂（pta）具有副作用小、穿透组织能力强、结构易于调节等优点，在癌症治疗和诊断方面具有很大的潜力。结合NIR-II荧光/光声（PA）成像和热效应的各种小分子PTA可以实时显示肿瘤位置并对肿瘤进行热照射，对癌症的早期诊断和精准治疗具有重要潜力。本文综述了在NIR-II成像引导下提高小分子PTAs光热治疗（PTT）效果的各种策略，包括提高光热转换效率（PCE）和光稳定性，提高生物相容性和特异性，以及通过协同治疗促进PTT。讨论了NIR-II小分子pta的应用前景和障碍。

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.