Márton Weber, Miklós Dékány, Andrea Nedves Nagyné, Csenge Anna Felegyi-Tóth, Suratno Suratno, Balázs Krámos, Enikő Bodó, Zoltán Béni, Attila Ványolós
{"title":"Gymnopeptides C and D, Highly <i>N</i>-Methylated Fungal Cyclopeptides.","authors":"Márton Weber, Miklós Dékány, Andrea Nedves Nagyné, Csenge Anna Felegyi-Tóth, Suratno Suratno, Balázs Krámos, Enikő Bodó, Zoltán Béni, Attila Ványolós","doi":"10.1021/acs.jnatprod.4c01132","DOIUrl":null,"url":null,"abstract":"<p><p>An in-depth chemical study of the fungus <i>Gymnopus fusipes</i> led to the discovery of two new cyclooctadecapeptides, gymnopeptides C and D, besides the known gymnopeptides A and B. Spectroscopic studies, as well as Marfey's analysis, and molecular modeling studies revealed the characteristic structural features of these cyclopeptides. Gymnopeptides A-D demonstrated antiproliferative activity on the A375 human cancer cell line, induced apoptosis by upregulation of caspase-3 activity, and acted as a suppressor of cell migration.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":" ","pages":"644-649"},"PeriodicalIF":3.6000,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1021/acs.jnatprod.4c01132","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/27 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
An in-depth chemical study of the fungus Gymnopus fusipes led to the discovery of two new cyclooctadecapeptides, gymnopeptides C and D, besides the known gymnopeptides A and B. Spectroscopic studies, as well as Marfey's analysis, and molecular modeling studies revealed the characteristic structural features of these cyclopeptides. Gymnopeptides A-D demonstrated antiproliferative activity on the A375 human cancer cell line, induced apoptosis by upregulation of caspase-3 activity, and acted as a suppressor of cell migration.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
