Efficacy of Pulp Revascularization in the Treatment of Apical Periodontitis in Mature Necrotic Teeth: An Umbrella Review

IF 1.5 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Australian Endodontic Journal Pub Date : 2025-02-28 DOI:10.1111/aej.12928

Wanderson Limeira de Sousa Barbosa, Luiz Renato Paranhos, Márcia Valente de Brito Dantas, Rômulo Dias Jesuino, João Marcos da Costa Ribeiro, Walbert A. Vieira, Felipe de Souza Matos

{"title":"Efficacy of Pulp Revascularization in the Treatment of Apical Periodontitis in Mature Necrotic Teeth: An Umbrella Review","authors":"Wanderson Limeira de Sousa Barbosa, Luiz Renato Paranhos, Márcia Valente de Brito Dantas, Rômulo Dias Jesuino, João Marcos da Costa Ribeiro, Walbert A. Vieira, Felipe de Souza Matos","doi":"10.1111/aej.12928","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>This umbrella review evaluated systematic reviews in clinical studies on pulp revascularisation in permanent mature necrotic teeth to determine their effectiveness in treating or preventing apical periodontitis. Seven of 294 articles retrieved from PubMed, LILACS, SciELO, Embase, Scopus, Web of Science, Cochrane and DANS Easy databases were included. The most used pulp revascularisation techniques were blood clots associated or not with platelet-poor plasma and umbilical cord mesenchymal stem cells. Meta-analysis and qualitative results from included articles indicated the efficacy of pulp revascularisation in mature necrotic teeth with similar success rates compared to non-surgical root canal treatment, pulp revascularisation in immature teeth, or apexification. Despite the low methodological quality and high risk of bias in most analysed systematic reviews, pulp revascularisation may be a successful treatment alternative for mature necrotic teeth. Well-conducted clinical trials are required to provide confirmatory evidence.</p>\n </div>","PeriodicalId":55581,"journal":{"name":"Australian Endodontic Journal","volume":"51 2","pages":"495-509"},"PeriodicalIF":1.5000,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Australian Endodontic Journal","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/aej.12928","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

This umbrella review evaluated systematic reviews in clinical studies on pulp revascularisation in permanent mature necrotic teeth to determine their effectiveness in treating or preventing apical periodontitis. Seven of 294 articles retrieved from PubMed, LILACS, SciELO, Embase, Scopus, Web of Science, Cochrane and DANS Easy databases were included. The most used pulp revascularisation techniques were blood clots associated or not with platelet-poor plasma and umbilical cord mesenchymal stem cells. Meta-analysis and qualitative results from included articles indicated the efficacy of pulp revascularisation in mature necrotic teeth with similar success rates compared to non-surgical root canal treatment, pulp revascularisation in immature teeth, or apexification. Despite the low methodological quality and high risk of bias in most analysed systematic reviews, pulp revascularisation may be a successful treatment alternative for mature necrotic teeth. Well-conducted clinical trials are required to provide confirmatory evidence.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

治疗成熟坏死牙根尖牙周炎的牙髓再血管化疗效：综述。

本综述对永久性成熟坏死牙髓血运重建的临床研究进行系统评价，以确定其治疗或预防根尖牙周炎的有效性。从PubMed、LILACS、SciELO、Embase、Scopus、Web of Science、Cochrane和DANS Easy数据库检索的294篇文章中有7篇被纳入。最常用的髓血运重建技术是与血小板缺乏的血浆和脐带间充质干细胞相关或不相关的血凝块。从纳入的文章中进行的荟萃分析和定性结果表明，与非手术根管治疗、未成熟牙髓血运重建或根尖化相比，成熟坏死牙髓血运重建的成功率相似。尽管在大多数分析的系统评价中，方法质量低，偏倚风险高，但牙髓血运重建术可能是成熟坏死牙齿的一种成功的治疗选择。需要进行良好的临床试验来提供确凿的证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Australian Endodontic Journal DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.50

自引率

6.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Australian Endodontic Journal provides a forum for communication in the different fields that encompass endodontics for all specialists and dentists with an interest in the morphology, physiology, and pathology of the human tooth, in particular the dental pulp, root and peri-radicular tissues. The Journal features regular clinical updates, research reports and case reports from authors worldwide, and also publishes meeting abstracts, society news and historical endodontic glimpses. The Australian Endodontic Journal is a publication for dentists in general and specialist practice devoted solely to endodontics. It aims to promote communication in the different fields that encompass endodontics for those dentists who have a special interest in endodontics.