Visible-Light-Driven Synergistic Se/Fe Catalysis for the Synthesis of 2-Aminoquinoline Derivatives

IF 5 1区 化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2025-03-03 DOI:10.1021/acs.orglett.5c00129
Yan-Ling Ji, Hong Wang, Xiang-Hong He, Junchao Zhu, Cheng Peng, Qian Zhao, Gu Zhan, Bo Han
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Abstract

A visible-light-driven Se/Fe synergistic catalytic reaction between isocyanides and amines has been developed, employing air as the terminal oxidant. This efficient strategy offers facile access to 2-aminoquinoline scaffolds. The use of cost-effective and readily available Fe(OTf)3 modulates the selenium catalyst’s oxidation state, enhancing the method’s environmental friendliness and practicality. The protocol is further distinguished by its good yields, broad substrate scope, and mild reaction conditions.

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可见光协同催化合成2-氨基喹啉衍生物的研究
以空气为末端氧化剂,建立了异氰化物与胺的可见光催化Se/Fe协同催化反应。这种有效的策略为2-氨基喹啉支架提供了方便的途径。利用低成本、易得的Fe(OTf)3调节了硒催化剂的氧化态,提高了该方法的环保性和实用性。该工艺收率高,底物范围广,反应条件温和。
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来源期刊
Organic Letters
Organic Letters 化学-有机化学
CiteScore
9.30
自引率
11.50%
发文量
1607
审稿时长
1.5 months
期刊介绍: Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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