Choroidal changes and association with Gaussian curvature in high myopic eyes with posterior staphyloma in ultra-wide-field optical coherence tomography angiography

IF 2.8 3区医学 Q1 OPHTHALMOLOGY Acta Ophthalmologica Pub Date : 2025-03-07 DOI:10.1111/aos.17477

Qing Zhao, Linxin Wei, Huan Chen, Yan Luo, Youxin Chen, Zhikun Yang

{"title":"Choroidal changes and association with Gaussian curvature in high myopic eyes with posterior staphyloma in ultra-wide-field optical coherence tomography angiography","authors":"Qing Zhao, Linxin Wei, Huan Chen, Yan Luo, Youxin Chen, Zhikun Yang","doi":"10.1111/aos.17477","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>To evaluate choroidal changes in high myopic (HM) patients with posterior staphyloma (PS) and explore their association with Gaussian curvature (<i>K</i>) using ultra-wide-field optical coherence tomography angiography (UWF-OCTA).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>HM patients with wide macular PS (Type I PS) and without any PS (control) were recruited. Highest <i>K</i> values (<i>K</i><sub>max</sub>) and choroidal parameters—vessel flow density (VFD), choroidal vascularity volume (CVV) and index (CVI), thickness, and volume—were compared in central and peripheral regions, and the fovea-centered 12-mm ETDRS quadrants of 24 × 20 mm UWF-OCTA images. Associations between choroidal parameters and <i>K</i> values in Type I PS eyes were analysed using multiple linear regression analysis, controlling for the confounding effect of AL.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Type I PS eyes showed increased <i>K</i><sub>max</sub> in various subregions (<i>p</i> < 0.05), except the 12-mm ETDRS superior quadrant. CVV, choroidal thickness, and volume were higher in the peripheral region of the UWF-SS-OCTA image in Type I PS eyes (<i>p</i> < 0.05). Central CVI and large and medium choroidal vascular layer-VFD were significantly lower in Type I PS eyes (<i>p</i> < 0.05). Correlation analysis revealed a negative association between macular <i>K</i><sub>max</sub> and central CVI (<i>p</i> < 0.05). In the peripheral region, <i>K</i><sub>max</sub> showed a positive correlation with choroidal thickness and volume (<i>p</i> < 0.05). These correlations were partially confirmed across several quadrants of the 12-mm ETDRS grid.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Type I PS eyes exhibit attenuated choroidal perfusion and a potentially reorganized choroidal structure and circulation, associated with Gaussian curvature severity. UWF-OCTA shows promise for non-invasive visualization of the choroidal alterations in PS.</p>\n </section>\n </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"103 8","pages":"998-1009"},"PeriodicalIF":2.8000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.17477","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Ophthalmologica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/aos.17477","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose

To evaluate choroidal changes in high myopic (HM) patients with posterior staphyloma (PS) and explore their association with Gaussian curvature (K) using ultra-wide-field optical coherence tomography angiography (UWF-OCTA).

Methods

HM patients with wide macular PS (Type I PS) and without any PS (control) were recruited. Highest K values (K_max) and choroidal parameters—vessel flow density (VFD), choroidal vascularity volume (CVV) and index (CVI), thickness, and volume—were compared in central and peripheral regions, and the fovea-centered 12-mm ETDRS quadrants of 24 × 20 mm UWF-OCTA images. Associations between choroidal parameters and K values in Type I PS eyes were analysed using multiple linear regression analysis, controlling for the confounding effect of AL.

Results

Type I PS eyes showed increased K_max in various subregions (p < 0.05), except the 12-mm ETDRS superior quadrant. CVV, choroidal thickness, and volume were higher in the peripheral region of the UWF-SS-OCTA image in Type I PS eyes (p < 0.05). Central CVI and large and medium choroidal vascular layer-VFD were significantly lower in Type I PS eyes (p < 0.05). Correlation analysis revealed a negative association between macular K_max and central CVI (p < 0.05). In the peripheral region, K_max showed a positive correlation with choroidal thickness and volume (p < 0.05). These correlations were partially confirmed across several quadrants of the 12-mm ETDRS grid.

Conclusion

Type I PS eyes exhibit attenuated choroidal perfusion and a potentially reorganized choroidal structure and circulation, associated with Gaussian curvature severity. UWF-OCTA shows promise for non-invasive visualization of the choroidal alterations in PS.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

超宽视场光学相干断层血管造影显示高度近视伴后葡萄肿的脉络膜变化及其与高斯曲率的关系。

目的：应用超宽视场光学相干断层血管造影（UWF-OCTA）评价高度近视（HM）后葡萄肿（PS）患者的脉络膜变化，并探讨其与高斯曲率(K)的关系。方法：招募有广角黄斑PS （I型PS）和无任何PS（对照组）的HM患者。比较24 × 20 mm UWF-OCTA图像的中央和周围区域以及以中央凹为中心的12 mm ETDRS象限的最高K值（Kmax）和脉络膜参数-血管血流密度（VFD）、脉络膜血管体积（CVV）和指数（CVI）、厚度和体积。采用多元线性回归分析I型PS眼脉络膜参数与K值的关系，控制al的混杂效应。结果：I型PS眼各亚区Kmax （p max）和中央CVI （p max）与脉络膜厚度和体积呈正相关(p)。I型PS眼表现为脉络膜灌注减弱，脉络膜结构和循环可能重组，与高斯曲率严重程度相关。UWF-OCTA显示了对PS脉络膜改变的无创可视化的希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.