Long-Term Outcomes in Crosslinking Therapy for Patients with Progressive Keratoconus.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Diagnostics Pub Date : 2025-03-05 DOI:10.3390/diagnostics15050626
Tevfik Serhat Bahar, Vedat Şahin, Yusuf Ayaz, Mustafa Ünal
{"title":"Long-Term Outcomes in Crosslinking Therapy for Patients with Progressive Keratoconus.","authors":"Tevfik Serhat Bahar, Vedat Şahin, Yusuf Ayaz, Mustafa Ünal","doi":"10.3390/diagnostics15050626","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background/Objectives:</b> To investigate the mid- and long-term postoperative follow-up results of corneal crosslinking (CXL) treatment (using epi-on and epi-off techniques) in progressive keratoconus. <b>Methods:</b> This was a retrospective single center study conducted between October 2013 and July 2020. Patients who received CXL treatment with a diagnosis of progressive keratoconus were included in the study. Preoperative and postoperative recorded examination findings of autorefractometry, visual acuity, endothelial cell counts by specular microscopy, and corneal topography were analyzed retrospectively. According to the latest measurements, the results were divided into two groups: measurements between 6 and 12 months and measurements between 1 and3 years. <b>Results:</b> A total of 290 operated eyes of 201 patients were included in the study. The mean age of the patients was 21.34 ± 5.77 years, and 119 (59.2%) were male. Epi-off CXL was performed on 269 (92.8%) eyes and epi-on procedure was performed on 21 (7.2%) eyes. CXL had no significant effect on visual acuity. Significant improvement was observed in topographic/keratometric features of the cornea both after 6-12 months and after 1-3 years. Significant decreases were observed in K1 (<i>p</i> < 0.001), K2 (<i>p</i> < 0.001), KM (<i>p</i> < 0.001) values compared to the initial level. <b>Conclusions:</b> CXL treatment is an important treatment method in the treatment of keratoconus, preserving visual functions, significantly reducing the severity of astigmatism, and stopping the progression of keratoconus. Additionally, although epi-off and epi-on CXL methods were compared in our study, the sample size was limited, and more comprehensive and long-term studies are needed.</p>","PeriodicalId":11225,"journal":{"name":"Diagnostics","volume":"15 5","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11898512/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3390/diagnostics15050626","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Background/Objectives: To investigate the mid- and long-term postoperative follow-up results of corneal crosslinking (CXL) treatment (using epi-on and epi-off techniques) in progressive keratoconus. Methods: This was a retrospective single center study conducted between October 2013 and July 2020. Patients who received CXL treatment with a diagnosis of progressive keratoconus were included in the study. Preoperative and postoperative recorded examination findings of autorefractometry, visual acuity, endothelial cell counts by specular microscopy, and corneal topography were analyzed retrospectively. According to the latest measurements, the results were divided into two groups: measurements between 6 and 12 months and measurements between 1 and3 years. Results: A total of 290 operated eyes of 201 patients were included in the study. The mean age of the patients was 21.34 ± 5.77 years, and 119 (59.2%) were male. Epi-off CXL was performed on 269 (92.8%) eyes and epi-on procedure was performed on 21 (7.2%) eyes. CXL had no significant effect on visual acuity. Significant improvement was observed in topographic/keratometric features of the cornea both after 6-12 months and after 1-3 years. Significant decreases were observed in K1 (p < 0.001), K2 (p < 0.001), KM (p < 0.001) values compared to the initial level. Conclusions: CXL treatment is an important treatment method in the treatment of keratoconus, preserving visual functions, significantly reducing the severity of astigmatism, and stopping the progression of keratoconus. Additionally, although epi-off and epi-on CXL methods were compared in our study, the sample size was limited, and more comprehensive and long-term studies are needed.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
背景/目的研究进行性角膜屈光不正患者角膜交联(CXL)治疗(采用外显子导入和外显子导出技术)的术后中长期随访结果。研究方法这是一项回顾性单中心研究,研究时间为 2013 年 10 月至 2020 年 7 月。研究对象包括接受 CXL 治疗并确诊为进展性角膜炎的患者。回顾性分析了术前和术后记录的检查结果,包括自动折射仪、视力、镜下内皮细胞计数和角膜地形图。根据最新的测量结果分为两组:6 至 12 个月的测量结果和 1 至 3 年的测量结果。结果研究共纳入了 201 名患者的 290 只手术眼。患者的平均年龄为(21.34 ± 5.77)岁,男性 119 人(59.2%)。269只(92.8%)眼睛接受了外显-关闭CXL手术,21只(7.2%)眼睛接受了外显-开启手术。CXL 对视力无明显影响。在 6-12 个月和 1-3 年后,角膜地形图/角膜测量特征均有明显改善。与初始水平相比,K1(p < 0.001)、K2(p < 0.001)、KM(p < 0.001)值明显下降。结论CXL 治疗是治疗角膜病的一种重要方法,它能保护视力功能,显著降低散光的严重程度,阻止角膜病的发展。此外,虽然我们的研究比较了外延-关闭和外延-开启 CXL 方法,但样本量有限,需要进行更全面、更长期的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
期刊最新文献
The Value of Clinical Decision Support in Healthcare: A Focus on Screening and Early Detection. Pain-Related White-Matter Changes Following Mild Traumatic Brain Injury: A Longitudinal Diffusion Tensor Imaging Pilot Study. Performance Comparison of Two In-House PCR Methods for Detecting Neisseria meningitidis in Asymptomatic Carriers and Antimicrobial Resistance Profiling. Fine-Tuned Machine Learning Classifiers for Diagnosing Parkinson's Disease Using Vocal Characteristics: A Comparative Analysis. Comparing ChatGPT 4.0's Performance in Interpreting Thyroid Nodule Ultrasound Reports Using ACR-TI-RADS 2017: Analysis Across Different Levels of Ultrasound User Experience.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1