{"title":"C−H Methylthiolation/d3-Methylthiolation of Pyrazole Skeleton via Interrupted Pummerer Reaction","authors":"Haofeng Shi, Fengxia Sun, Jialiang Wu, Jiaxin He, Yuli Sun, Yunfei Du","doi":"10.1002/ajoc.202400639","DOIUrl":null,"url":null,"abstract":"<p>The reaction of a series of pyrazole derivatives with DMSO/ -DMSO-<i>d<sub>6</sub></i> and thionyl chloride conveniently afforded the 4-thiolated pyrazole products under metal-free conditions. This C−H functionalization/elelctrophilic thiolation process is postulated to involve the <i>in situ</i> generation of the electrophilic hypochlorothioite <i>via</i> interrupted Pummerer reaction, followed with the electrophilic methylthiolation of pyrazole skeleton.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 3","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202400639","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
The reaction of a series of pyrazole derivatives with DMSO/ -DMSO-d6 and thionyl chloride conveniently afforded the 4-thiolated pyrazole products under metal-free conditions. This C−H functionalization/elelctrophilic thiolation process is postulated to involve the in situ generation of the electrophilic hypochlorothioite via interrupted Pummerer reaction, followed with the electrophilic methylthiolation of pyrazole skeleton.
期刊介绍：
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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