Assessing Mucosal Recovery During the First 15 Months of Adopting a Gluten-Free Diet in Children With Celiac Disease.

IF 7.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY American Journal of Gastroenterology Pub Date : 2025-03-14 DOI:10.14309/ajg.0000000000003400

Denis Chang, Madison Wong, Cleo R Davidowitz, Imad Absah, Vahe Badalyan, Mohammad K Chaaban, Lisa Fahey, Daniela M Isaac, Maya Khanna, Marihan Lansing, Edwin Liu, Catherine Raber, Arunjot Singh, Marisa G Stahl, Catharine M Walsh, Jocelyn A Silvester, Maureen M Leonard

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Abstract

Introduction: Determine contemporary rates of early mucosal recovery in children with celiac disease (CeD).

Methods: Multicenter retrospective cohort study in Canada and the United States. Children diagnosed with CeD between 2016 and 2021 who underwent a follow-up biopsy within 15 months of diagnosis were included.

Results: Overall, 96 of 130 children (74%) had mucosal recovery, including 48% children (12/25) who were assessed within 3 months. Musculoskeletal symptoms at diagnosis were the only clinical characteristic associated with persistent enteropathy.

Discussion: While mucosal recovery can occur within months, more than a quarter of children with CeD had persistent enteropathy within 15 months of treatment.

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评估乳糜泻患儿在采用无麸质饮食后最初 15 个月的粘膜恢复情况。

目的：确定乳糜泻（CeD）患儿的早期黏膜恢复率。方法：在加拿大和美国进行多中心回顾性队列研究。2016年至2021年间诊断为CeD的儿童在诊断后15个月内接受了随访活检。结果：总体而言，96/130（74%）患儿粘膜恢复，其中48%（12/25）患儿在3个月内进行评估。诊断时的肌肉骨骼症状是与持续性肠病相关的唯一临床特征。结论：虽然粘膜可以在几个月内恢复，但超过四分之一的CeD患儿在治疗15个月内出现持续性肠病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.

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