Chronic diarrhea related to neuroblastoma: the important role of vasoactive intestinal peptide in tumor pathology and survival.

IF 3.4 2区医学 Q2 ONCOLOGY BMC Cancer Pub Date : 2025-03-13 DOI:10.1186/s12885-025-13870-1

Meng-Ying Cao, Kun Zhang, Jing Guo, Fang Dong, Ling-Fen Xu

{"title":"Chronic diarrhea related to neuroblastoma: the important role of vasoactive intestinal peptide in tumor pathology and survival.","authors":"Meng-Ying Cao, Kun Zhang, Jing Guo, Fang Dong, Ling-Fen Xu","doi":"10.1186/s12885-025-13870-1","DOIUrl":null,"url":null,"abstract":"Background: To analyze the correlation between vasoactive intestinal peptide (VIP) protein expression in neuroblastoma (NB) tumors and NB clinical features and prognosis.Methods: Clinical data were collected from 91 patients with NB aged < 18 years who underwent tumor resection at the Shengjing Hospital of China Medical University between January 2015 and December 2021. VIP expression levels in tumor tissues were evaluated by immunohistochemistry, and the correlation between VIP expression intensity and NB clinical characteristics and prognosis was analyzed.Results: VIP expression was detected in 25/91 patients with NB (27.5%). VIP expression intensity was significantly increased in children with diarrhea and hypokalemia (P < 0.001, and P < 0.001, respectively), and was significantly associated with histopathological classification, prognosis, bone marrow metastasis, and tumor stage (P = 0.003, P = 0.036, P = 0.018, and P = 0.027, respectively). VIP expression intensity was positively correlated with synaptophysin expression (rs = 0.342, P = 0.001), and negatively correlated with expression of chromogranin A and proliferating cell nuclear antigen (Ki67) (rs = -0.265, P = 0.011; rs = -0.317, P = 0.002, respectively). There were no significant differences in VIP expression levels according to sex, age, tumor site, or levels of neuron specific enolase, 24-h urine vanillylmandelic acid, and lactate dehydrogenase.Conclusions: VIP is one of the main causes of refractory diarrhea in patients with NB, and may be a potential biomarker of good prognosis.Trial registration: Retrospectively registered.","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":"25 1","pages":"457"},"PeriodicalIF":3.4000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905442/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12885-025-13870-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: To analyze the correlation between vasoactive intestinal peptide (VIP) protein expression in neuroblastoma (NB) tumors and NB clinical features and prognosis.

Methods: Clinical data were collected from 91 patients with NB aged < 18 years who underwent tumor resection at the Shengjing Hospital of China Medical University between January 2015 and December 2021. VIP expression levels in tumor tissues were evaluated by immunohistochemistry, and the correlation between VIP expression intensity and NB clinical characteristics and prognosis was analyzed.

Results: VIP expression was detected in 25/91 patients with NB (27.5%). VIP expression intensity was significantly increased in children with diarrhea and hypokalemia (P < 0.001, and P < 0.001, respectively), and was significantly associated with histopathological classification, prognosis, bone marrow metastasis, and tumor stage (P = 0.003, P = 0.036, P = 0.018, and P = 0.027, respectively). VIP expression intensity was positively correlated with synaptophysin expression (r_s = 0.342, P = 0.001), and negatively correlated with expression of chromogranin A and proliferating cell nuclear antigen (Ki67) (r_s = -0.265, P = 0.011; r_s = -0.317, P = 0.002, respectively). There were no significant differences in VIP expression levels according to sex, age, tumor site, or levels of neuron specific enolase, 24-h urine vanillylmandelic acid, and lactate dehydrogenase.

Conclusions: VIP is one of the main causes of refractory diarrhea in patients with NB, and may be a potential biomarker of good prognosis.

Trial registration: Retrospectively registered.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

求助全文

约1分钟内获得全文去求助

来源期刊

BMC Cancer 医学-肿瘤学

CiteScore

6.00

自引率

2.60%

发文量

1204

审稿时长

6.8 months

期刊介绍： BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.