Chronic diarrhea related to neuroblastoma: the important role of vasoactive intestinal peptide in tumor pathology and survival.

IF 3.4 2区医学 Q2 ONCOLOGY BMC Cancer Pub Date : 2025-03-13 DOI:10.1186/s12885-025-13870-1

Meng-Ying Cao, Kun Zhang, Jing Guo, Fang Dong, Ling-Fen Xu

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Abstract

Background: To analyze the correlation between vasoactive intestinal peptide (VIP) protein expression in neuroblastoma (NB) tumors and NB clinical features and prognosis.

Methods: Clinical data were collected from 91 patients with NB aged < 18 years who underwent tumor resection at the Shengjing Hospital of China Medical University between January 2015 and December 2021. VIP expression levels in tumor tissues were evaluated by immunohistochemistry, and the correlation between VIP expression intensity and NB clinical characteristics and prognosis was analyzed.

Results: VIP expression was detected in 25/91 patients with NB (27.5%). VIP expression intensity was significantly increased in children with diarrhea and hypokalemia (P < 0.001, and P < 0.001, respectively), and was significantly associated with histopathological classification, prognosis, bone marrow metastasis, and tumor stage (P = 0.003, P = 0.036, P = 0.018, and P = 0.027, respectively). VIP expression intensity was positively correlated with synaptophysin expression (r_s = 0.342, P = 0.001), and negatively correlated with expression of chromogranin A and proliferating cell nuclear antigen (Ki67) (r_s = -0.265, P = 0.011; r_s = -0.317, P = 0.002, respectively). There were no significant differences in VIP expression levels according to sex, age, tumor site, or levels of neuron specific enolase, 24-h urine vanillylmandelic acid, and lactate dehydrogenase.

Conclusions: VIP is one of the main causes of refractory diarrhea in patients with NB, and may be a potential biomarker of good prognosis.

Trial registration: Retrospectively registered.

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神经母细胞瘤相关慢性腹泻：血管活性肠肽在肿瘤病理及生存中的重要作用。

背景：分析成神经细胞瘤（NB）肿瘤血管活性肠肽（VIP）蛋白表达与NB临床特征及预后的关系。方法：收集91例老年NB患者的临床资料。结果：91例NB患者中有25例（27.5%）检测到VIP表达。腹泻和低钾血症患儿VIP表达强度显著升高（P = 0.342, P = 0.001），与铬粒蛋白A和增殖细胞核抗原（Ki67）表达呈负相关(rs = -0.265, P = 0.011；rs = -0.317, P = 0.002)。VIP的表达水平在性别、年龄、肿瘤部位、神经元特异性烯醇化酶、24小时尿香草扁豆酸和乳酸脱氢酶水平上无显著差异。结论：VIP是NB患者难治性腹泻的主要原因之一，可能是预后良好的潜在生物标志物。试验注册：回顾性注册。

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来源期刊

BMC Cancer 医学-肿瘤学

CiteScore

6.00

自引率

2.60%

发文量

1204

审稿时长

6.8 months

期刊介绍： BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.