Elaine Debien, Felix Goulet, Lee Silverman, Esther Millette, Qian Wu
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引用次数: 0
Abstract
Two dark and raised foci were observed on the left hemisphere of the brain of a 3-year-old cynomolgus monkey during the routine necropsy procedures of a preclinical toxicity study. Microscopic examination revealed a lesion in the cerebral cortex at the junction of the parietal and occipital lobes, consisting of disorganized, but generally well-circumscribed collections of mixed glial and neuronal cells within a fibrillar stroma. Numerous eosinophilic granular bodies, brown pigment-laden macrophages, and lymphocytic infiltrates were also noted. Immunohistochemical staining for glial fibrillary acidic protein, neurofilament, and Ki-67, as well as histochemical stains Masson's Trichrome and Klüver-Barrera confirmed the presence of both glial and neuronal cells within a collagenous stroma, without significant proliferation. Both histopathological and immuno/histochemical stains were consistent with a glioneuronal hamartoma. This report describes the first case of such a lesion in a nonhuman primate.
期刊介绍:
Toxicologic Pathology is dedicated to the promotion of human, animal, and environmental health through the dissemination of knowledge, techniques, and guidelines to enhance the understanding and practice of toxicologic pathology. Toxicologic Pathology, the official journal of the Society of Toxicologic Pathology, will publish Original Research Articles, Symposium Articles, Review Articles, Meeting Reports, New Techniques, and Position Papers that are relevant to toxicologic pathology.