{"title":"SPO11 cuts!","authors":"Sara Hariri, Neil Hunter","doi":"10.1038/s41422-025-01093-9","DOIUrl":null,"url":null,"abstract":"<p><b>During meiosis, SPO11-catalyzed DNA double-strand breaks (DSBs) initiate homologous recombination, which is essential for accurate chromosome segregation and enhances genome diversification. 28 years after its discovery, three new studies report the reconstitution of SPO11-catalyzed DSB formation in vitro</b>.</p>","PeriodicalId":9926,"journal":{"name":"Cell Research","volume":"16 1","pages":""},"PeriodicalIF":28.1000,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Research","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41422-025-01093-9","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
During meiosis, SPO11-catalyzed DNA double-strand breaks (DSBs) initiate homologous recombination, which is essential for accurate chromosome segregation and enhances genome diversification. 28 years after its discovery, three new studies report the reconstitution of SPO11-catalyzed DSB formation in vitro.
期刊介绍：
Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.
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