The Effect of Kisspeptin Preparations on the Expression of CRH, GRH, GNRHR1, and OXT Genes in the Brain of Danio rerio after Social Isolation

IF 0.4 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2025-03-18 DOI:10.1134/S199075082460122X

A. P. Perova, V. A. Golts, A. V. Lizunov, E. A. Sekste, E. R. Bychkov, A. A. Bairamov, A. A. Lebedev, P. D. Shabanov

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Abstract

The effect of kisspeptin preparation on the expression of the genes of hormonal regulation of sexual behavior in Danio rerio fish was studied after the effect of social isolation. For this, fish were placed in individual containers for 48 h to model the conditions of social isolation, after which kisspeptin was administered, and they were again placed in the conditions of social isolation for 1 day. It was established that changes in the expression of the crh, grh, gnrhr1, and oxt genes occurred in the fish brain after social isolation upon administration of kisspeptin peptide. It is interesting that the expression of these genes changed both under isolation conditions and during subsequent effect of kisspeptin, which indicates possible mechanisms of regulating stress and behavioral responses through hormonal systems.

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Kisspeptin制剂对社会隔离后家兔脑CRH、GRH、GNRHR1和OXT基因表达的影响

研究了kisspeptin制剂对达尼奥鱼性行为激素调控基因表达的影响。为此，将鱼放在单独的容器中48小时以模拟社会隔离条件，之后给予kisspeptin，然后再次置于社会隔离条件下1天。我们发现，在kisspeptin肽的作用下，社会隔离后的鱼脑中crh、grh、gnrhr1和oxt基因的表达发生了变化。有趣的是，这些基因的表达在分离条件下和kisspeptin的后续作用下都发生了变化，这表明可能通过激素系统调节应激和行为反应的机制。

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Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

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1.10

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0.00%

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期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.