Intranasal bacteria transport obesity drugs to the brain

IF 41.7 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Nature biotechnology Pub Date : 2025-03-17 DOI:10.1038/s41587-025-02598-9
Iris Marchal
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鼻内细菌将减肥药运送到大脑
经嗅上皮(OE)鼻内给药脑靶向治疗已成为一种绕过保护性血脑屏障的策略,但这种给药途径仍然有限,因为它需要高剂量和频繁给药。Shen等人在《细胞》杂志上发表文章称,他们通过设计一种天然存在于鼻子内的细菌菌株,改善了oe介导的大脑递送。作者利用鼻腔微生物群来提高OE的靶向性,发现了共生细菌植物乳杆菌(Lactobacillus plantarum, Lp),它可以自然地特异性结合OE。他们首先用示踪分子FITC标记Lp,以跟踪潜在治疗有效载荷到OE的运输,结果显示,每天给药3天后,FITC在OE下方的固有层中积累。7天后,它到达大脑的嗅球,随着时间的推移,它在那里积累,同时也扩散到大脑的其他区域。
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来源期刊
Nature biotechnology
Nature biotechnology 工程技术-生物工程与应用微生物
CiteScore
63.00
自引率
1.70%
发文量
382
审稿时长
3 months
期刊介绍: Nature Biotechnology is a monthly journal that focuses on the science and business of biotechnology. It covers a wide range of topics including technology/methodology advancements in the biological, biomedical, agricultural, and environmental sciences. The journal also explores the commercial, political, ethical, legal, and societal aspects of this research. The journal serves researchers by providing peer-reviewed research papers in the field of biotechnology. It also serves the business community by delivering news about research developments. This approach ensures that both the scientific and business communities are well-informed and able to stay up-to-date on the latest advancements and opportunities in the field. Some key areas of interest in which the journal actively seeks research papers include molecular engineering of nucleic acids and proteins, molecular therapy, large-scale biology, computational biology, regenerative medicine, imaging technology, analytical biotechnology, applied immunology, food and agricultural biotechnology, and environmental biotechnology. In summary, Nature Biotechnology is a comprehensive journal that covers both the scientific and business aspects of biotechnology. It strives to provide researchers with valuable research papers and news while also delivering important scientific advancements to the business community.
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