{"title":"Strained diradicaloids for σ-bond-insertion reactions: A breakthrough in drug discovery","authors":"Yoshio Barrera, Florian F. Mulks","doi":"10.1016/j.chempr.2025.102524","DOIUrl":null,"url":null,"abstract":"Houk, Garg, and colleagues report in <em>Nature</em> a new and intriguing synthetic method for coupling strained cyclic allenes and bicyclo[1.1.0]butanes through <strong><em>σ</em></strong>-bond insertion along a diradical pathway under mild conditions and ambient temperature. Geometric distortion induces diradical behavior, driving the reaction. This study enables the direct synthesis of functionalized bicyclo[2.1.1]hexanes, opening new avenues in drug discovery.","PeriodicalId":268,"journal":{"name":"Chem","volume":"88 1","pages":""},"PeriodicalIF":19.1000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chem","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.chempr.2025.102524","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Houk, Garg, and colleagues report in Nature a new and intriguing synthetic method for coupling strained cyclic allenes and bicyclo[1.1.0]butanes through σ-bond insertion along a diradical pathway under mild conditions and ambient temperature. Geometric distortion induces diradical behavior, driving the reaction. This study enables the direct synthesis of functionalized bicyclo[2.1.1]hexanes, opening new avenues in drug discovery.
期刊介绍：
Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.
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