Identification of Indazole- and Azaindazole-Substituted Cyclopentapyrroles as G2019S Leucine-Rich Repeat Kinase 2 Inhibitors for the Treatment of CNS Disorders.

IF 4 3区医学 Q2 CHEMISTRY, MEDICINAL ACS Medicinal Chemistry Letters Pub Date : 2025-02-13 eCollection Date: 2025-03-13 DOI:10.1021/acsmedchemlett.5c00045

Siyan Feng, Steven H Liang

引用次数: 0

Abstract

This patent describes a novel class of novel indazole/azaindazole-substituted cyclopentapyrroles, which selectively inhibit the Leucine-Rich Repeat Kinase 2 (LRRK2) with G2019S mutation. These LRRK2 inhibitors are proposed for treating Parkinson's diseases, Alzheimer's disease, and other central nervous system (CNS) disorders.

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吲哚唑和叠氮唑取代环五吡咯作为G2019S富亮氨酸重复激酶2抑制剂治疗中枢神经系统疾病的鉴定

本专利描述了一类新型茚唑/氮杂唑取代环五吡咯，可选择性抑制G2019S突变的富亮氨酸重复激酶2 （LRRK2）。这些LRRK2抑制剂被建议用于治疗帕金森病、阿尔茨海默病和其他中枢神经系统（CNS）疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

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