Functionalized extracellular vesicles of mesenchymal stem cells for regenerative medicine.

IF 12.6 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of Nanobiotechnology Pub Date : 2025-03-18 DOI:10.1186/s12951-025-03300-6

Donghyeon Yoo, Se Young Jung, Dabin Go, Ji Yeong Park, Dong Gil You, Won-Kyo Jung, Yuce Li, Jianxun Ding, Jae Hyung Park, Wooram Um

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Abstract

Stem cell-derived extracellular vesicles (EVs) have emerged as a safe and potent alternative to regenerative medicine in recent decades. Furthermore, the adjustment of EV functions has been recently enabled by certain stem cell preconditioning methods, providing an exceptional opportunity to enhance the therapeutic potential or confer additional functions of stem cell-derived EVs. In this review, we discuss the recent progress of functionalized EVs, based on stem cell preconditioning, for treating various organ systems, such as the musculoskeletal system, nervous system, integumentary system, cardiovascular system, renal system, and respiratory system. Additionally, we summarize the expected outcomes of preconditioning methods for stem cells and their EVs. With recent progress, we suggest considerations and future directions for developing personalized medicine based on preconditioned stem cell-derived EVs.

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用于再生医学的间充质干细胞功能化细胞外囊泡。

近几十年来，干细胞来源的细胞外囊泡（ev）已成为一种安全有效的再生医学替代品。此外，最近通过某些干细胞预处理方法实现了EV功能的调节，这为增强干细胞衍生EV的治疗潜力或赋予其额外功能提供了难得的机会。本文综述了基于干细胞预处理的功能化电动汽车在肌肉骨骼系统、神经系统、皮肤系统、心血管系统、肾脏系统和呼吸系统等器官系统治疗方面的最新进展。此外，我们总结了干细胞及其电动汽车预处理方法的预期结果。根据最近的进展，我们提出了基于预处理干细胞衍生的电动汽车开发个性化医疗的考虑和未来方向。

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来源期刊

Journal of Nanobiotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

13.90

自引率

4.90%

发文量

493

审稿时长

16 weeks

期刊介绍： Journal of Nanobiotechnology is an open access peer-reviewed journal communicating scientific and technological advances in the fields of medicine and biology, with an emphasis in their interface with nanoscale sciences. The journal provides biomedical scientists and the international biotechnology business community with the latest developments in the growing field of Nanobiotechnology.