{"title":"Precision Tuning of ABA Signaling by Ubiquitination of ABA Receptors: Modulating Protein Activity and Localization.","authors":"Chang Du, Zhonghui Zhang","doi":"10.1093/jxb/eraf104","DOIUrl":null,"url":null,"abstract":"<p><p>Ubiquitination, a form of post-translational modification, precisely orchestrates plant hormone signaling by modulating protein activity, localization, assembly, and interaction. The RING-type E3 ubiquitin ligase RSL1 and the CUL4-DDB1-DWD-type E3 ubiquitin ligase complex promote the degradation of ABA receptors by mediating their polyubiquitination. In contrast, Arabidopsis DOA10A, an E3 ubiquitin ligase associated with ERAD, enhances the localization of ABA receptors to the plasma membrane through mono-ubiquitination, thereby improving their function in signal perception. Different mechanisms mediating polyubiquitination or monoubiquitination play a decisive role in determining the fate of ABA receptors.</p>","PeriodicalId":15820,"journal":{"name":"Journal of Experimental Botany","volume":" ","pages":""},"PeriodicalIF":5.6000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Experimental Botany","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/jxb/eraf104","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PLANT SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Ubiquitination, a form of post-translational modification, precisely orchestrates plant hormone signaling by modulating protein activity, localization, assembly, and interaction. The RING-type E3 ubiquitin ligase RSL1 and the CUL4-DDB1-DWD-type E3 ubiquitin ligase complex promote the degradation of ABA receptors by mediating their polyubiquitination. In contrast, Arabidopsis DOA10A, an E3 ubiquitin ligase associated with ERAD, enhances the localization of ABA receptors to the plasma membrane through mono-ubiquitination, thereby improving their function in signal perception. Different mechanisms mediating polyubiquitination or monoubiquitination play a decisive role in determining the fate of ABA receptors.
期刊介绍：
The Journal of Experimental Botany publishes high-quality primary research and review papers in the plant sciences. These papers cover a range of disciplines from molecular and cellular physiology and biochemistry through whole plant physiology to community physiology.
Full-length primary papers should contribute to our understanding of how plants develop and function, and should provide new insights into biological processes. The journal will not publish purely descriptive papers or papers that report a well-known process in a species in which the process has not been identified previously. Articles should be concise and generally limited to 10 printed pages.
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