Genetic characterization of rotavirus A strains circulating in children under 5 years of age with acute gastroenteritis in Tehran, Iran, in 2023-2024: dissemination of the emerging equine-like G3P[8]-I2-E2 DS-1-like strains.

IF 3.6 4区医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of General Virology Pub Date : 2025-03-01 DOI:10.1099/jgv.0.002088

Somayeh-Sadat Hosseini-Fakhr, Somayeh Jalilvand, Ali Maleki, Atefeh Kachooei, Farzane Behnezhad, Mahtab Mir-Hosseinian, Seiedehparnian Taghvaei, Sayed Mahdi Marashi, Zabihollah Shoja

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Abstract

The present study was conducted to monitor the genotype diversity of circulating species A rotavirus (RVA) in Iran. A total of 300 faecal specimens were collected from children under 5 years of age hospitalized for acute gastroenteritis between October 2023 and October 2024. G3P[8] represented 72.91% (70/96) of all RVA-positive samples, further subdivided into equine-like G3P[8]-I2-E2 DS-1-like and human G3P[8]-I1-E1 Wa-like. A retrospective genetic analysis of G3P[8] strains isolated from 2015 to 2017 was also performed and showed that G3P[8] strains belong to the G3P[8]-E1-I1 Wa-like genetic pattern, which is typically similar to human G3P[8] Wa-like strains in this study. The emergence of equine-like G3P[8] DS-1-like strains in Iran may not be related to selection pressure from rotavirus vaccination, but rather to cross-border migration of rotavirus strains due to population movements.

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来源期刊

Journal of General Virology 医学-病毒学

CiteScore

7.70

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： JOURNAL OF GENERAL VIROLOGY (JGV), a journal of the Society for General Microbiology (SGM), publishes high-calibre research papers with high production standards, giving the journal a worldwide reputation for excellence and attracting an eminent audience.