{"title":"Proteome-wide discovery of phage anti-defense proteins by Alphafold2","authors":"Zhifu Han, Yu Cao, Jijie Chai","doi":"10.1016/j.molcel.2025.02.020","DOIUrl":null,"url":null,"abstract":"In a recent <em>Cell</em> study, Yirmiya et al.,<span><span><sup>1</sup></span></span> using AlphaFold2-Multimer co-folding analyses, identify multiple phage inhibitors of bacterial defense systems on a proteome-wide scale and uncover a novel inhibition mechanism of these anti-defense proteins. The study significantly promotes our understanding of phage-bacteria interactions.","PeriodicalId":18950,"journal":{"name":"Molecular Cell","volume":"34 1","pages":""},"PeriodicalIF":14.5000,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Cell","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.molcel.2025.02.020","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In a recent Cell study, Yirmiya et al.,1 using AlphaFold2-Multimer co-folding analyses, identify multiple phage inhibitors of bacterial defense systems on a proteome-wide scale and uncover a novel inhibition mechanism of these anti-defense proteins. The study significantly promotes our understanding of phage-bacteria interactions.
期刊介绍：
Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
