Karla Pacheco de Melo, Giovana Salla Siqueira de Souza, Emad Ibrahim, Charles M Lynne, Nancy L Brackett, Ricardo Pimenta Bertolla, Mariana Camargo
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引用次数: 0
Abstract
Objective: To evaluate seminal plasma levels of Biglycan, Cystatin-S, β-2 microglobulin and inflammasome proteins and to investigate their role in seminal toxicity in men with spinal cord injury (SCI).
Study design: cross-sectional study.
Setting: Miami Project to Cure Paralysis - University of Miami / Miller School of Medicine and Federal University of Sao Paulo.
Participants: Eight men with spinal cord injury and eight men without spinal cord injury (controls).
Intervention: none. Outcome measures: semen analysis as per WHO 2010 guidelines; seminal plasma ELISA for IL-1β, IL-18 and caspase-1; and Western blotting for Biglycan, β-2microglobulin and Cystatin-S proteins.
Results: Proteins from the inflammasome complex are elevated in men with SCI, as previously described. In addition, β-2-microgobulin, Cystatin-S and two different isoforms of Byglican are elevated in men with SCI.
Conclusion: a different pathway to activate the inflammasome complex is present in men with spinal cord injury. This pathway can be a potential target for new interventions in the future.
期刊介绍：
For more than three decades, The Journal of Spinal Cord Medicine has reflected the evolution of the field of spinal cord medicine. From its inception as a newsletter for physicians striving to provide the best of care, JSCM has matured into an international journal that serves professionals from all disciplines—medicine, nursing, therapy, engineering, psychology and social work.
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