{"title":"Pathways that limit differentiation of oligodendrocyte progenitors in the aging brain","authors":"","doi":"10.1038/s43587-025-00848-8","DOIUrl":null,"url":null,"abstract":"This study generated a transgenic mouse line that enables the in vivo visualization, isolation and transcriptional profiling of oligodendrocyte precursor cells (OPCs) across the lifespan. Analysis of gene-expression changes reveals how OPCs in the cerebral cortex respond to the aging brain environment and highlights pathways that inhibit their differentiation.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":"5 4","pages":"544-545"},"PeriodicalIF":19.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-025-00848-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
This study generated a transgenic mouse line that enables the in vivo visualization, isolation and transcriptional profiling of oligodendrocyte precursor cells (OPCs) across the lifespan. Analysis of gene-expression changes reveals how OPCs in the cerebral cortex respond to the aging brain environment and highlights pathways that inhibit their differentiation.
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