Clearance of Cell-Free DNA: A Novel Target for Therapeutic Utilization in Multiple Systemic Disorders.

IF 5.5 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2025-04-14 Epub Date: 2025-04-03 DOI:10.1021/acsbiomaterials.5c00049

Wenjun Zhang, Xuan Jing, Bing Li, Xiuping Wu

引用次数: 0

Abstract

Cell-free DNA (cfDNA) holds significant promise for diagnostic and therapeutic advancements in medicine. This review delineates the utility of cfDNA in diagnostics and its therapeutic potential through clearance mechanisms for an array of diseases. Damage-associated molecular patterns (DAMPs) are endogenous molecules released by host cells during stress, or injury. As a trigger for inflammatory responses via damage-associated molecular patterns (DAMPs), cfDNA's removal via nanotechnological approaches can attenuate inflammation and promote tissue repair. While the application of cfDNA clearance is particularly auspicious in cancer, sepsis, and inflammatory conditions, it is confronted with challenges including toxicity, specificity, and the rigors of clinical trial validation. Collectively, this review delineates novel therapeutic targets to inform the development of innovative treatment strategies.

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清除无细胞DNA：治疗多种系统性疾病的新靶点。

无细胞DNA （cfDNA）在医学诊断和治疗进步方面具有重要的前景。本文综述了cfDNA在诊断中的应用及其通过清除机制对一系列疾病的治疗潜力。损伤相关分子模式（DAMPs）是宿主细胞在应激或损伤时释放的内源性分子。作为通过损伤相关分子模式（DAMPs）引发炎症反应的触发因素，通过纳米技术方法去除cfDNA可以减轻炎症并促进组织修复。虽然cfDNA清除率在癌症、败血症和炎症等疾病中的应用尤其乐观，但它面临着包括毒性、特异性和临床试验验证的严密性在内的挑战。总的来说，这篇综述描述了新的治疗靶点，为创新治疗策略的发展提供了信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

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