Initiation of enteral feeding as per current protocol (at 24 h) versus as per clinical status (from 6 h onwards) in neonates born with antenatal reversed end diastolic flow (REDF) in the umbilical artery Doppler: a pilot randomized controlled trial

Abstract

To compare the effects of initiating feeds at 24 h versus at 6 h in neonates with reversed end-diastolic flow (REDF) and determine the incidence of feed intolerance (FI) and necrotizing enterocolitis (NEC). Pilot randomized controlled trial. Neonates with REDF (n = 52) were randomized to start feeds at 6 h (n = 26) or 24 h (n = 26) to assess FI, NEC, time to full feeds, sepsis, mortality, weight and gestation at discharge, and hospital stay. FI was observed in 14 (54%) neonates in 6 h group and 17 (65%) in 24 h group, with comparable NEC rates. Neonates in the 6 h group achieved full feeds faster (8 vs. 11 days) and had shorter hospital stay (17 vs. 32 days). Death and sepsis rates were similar. Feed initiation at 6 h in REDF neonates did not increase the risk of FI or NEC. Clinical trial registry of India (CTRI/2023/02/050025); 23/02/2023.