Letian Xu, Alena M. Vasquez, Jose M. Medina, Juntao Sun, Keary M. Engle
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引用次数: 0
Abstract
A Brønsted-acid-mediated cyclocondensation of 2-alkenylanilines and (hetero)arylethanones to access dihydro-1-benzazepines is reported. Various 2-alkenylanilines and electron-deficient (hetero)arylethanones are tolerated and afford moderate to good yields. Coordination of 2-pyridinyl-substituted dihydro-1-benzazepines to palladium(II) demonstrates their ability to serve as novel N,N-bidentate ligand scaffolds. Isotope labeling and reactivity trends are consistent with an aza-8π-electrocyclization mechanism for this medium-sized ring-forming reaction.
期刊介绍：
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.
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