Nonsteroidal antiinflammatory agents. XVIII - Stereomeric optically active halogenophenyl-biphenylyl-hydroxypropionic acids.

Il Farmaco; edizione scientifica Pub Date : 1988-11-01
L Varoli, S Burnelli, A Guarnieri, N Ghedini, G Scapini, S Ferri, E Cavicchini
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Abstract

The optically active stereomers of some 3-(fluoro-, chloro-, bromophenyl)-2-biphenylyl-3-hydroxypropionic acids were prepared and tested for antiinflammatory activity. Surprisingly, the four bromo-isomers were the most active ones, particularly in the threo configuration.

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非甾体类抗炎药。立体旋光性卤代苯基-联苯基-羟基丙酸。
制备了几种3-(氟、氯、溴苯基)-2-联苯基-3-羟基丙酸的旋光性对映体,并对其抗炎活性进行了测试。令人惊讶的是,四个溴同分异构体是最活跃的,特别是在三个构型中。
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