“Rapid identification of carbapenemases and in vitro synergy testing of ceftazidime-avibactam with aztreonam in extensively drug-resistant Gram-negative pathogens: Establishing the realm of promise”
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引用次数: 0
Abstract
This study evaluated the effectiveness of ceftazidime-avibactam (CZA) alone and in combination with aztreonam (ATM) against 50 extensively drug-resistant (XDR) Gram-negative bacteria (GNB) isolates using disk stacking method. New Delhi metallo-beta-lactamase (NDM) was the predominant carbapenemase, detected in 50% of isolates showing synergy. The CZA-ATM combination demonstrated synergy in 40% of isolates, with 75% of patients receiving this combination achieving microbiological clearance. This simple, rapid synergy testing method can guide effective therapeutic decisions in resource-limited settings.
期刊介绍：
Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study.
Review articles, Special Articles or Guest Editorials are accepted on invitation.
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