Cheawon Lee , Yoon Ha Kim , Myeong Gyun Choi , Jong Woon Kim , Clara Yongjoo Park
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引用次数: 0
Abstract
The mechanisms of placental magnesium (Mg) transport are unknown, especially in twins. We cross-sectionally investigated the association of Mg transport-related protein mRNA expression with serum Mg, placental Mg concentration (p[Mg]), and placenta weight in singleton and twin placentas from 67 mothers. Maternal and cord blood serum Mg were not associated with placental mRNA expression. TRPM6 and TRPM7 mRNAs were positively associated with placental weight in twins while TRPM7 mRNA was positively associated with p[Mg] in singletons. In placentas of relatively healthy women, TRPM6 and TRPM7 may regulate p[Mg] and growth, rather than serum Mg, especially in twin placentas.
期刊介绍：
Placenta publishes high-quality original articles and invited topical reviews on all aspects of human and animal placentation, and the interactions between the mother, the placenta and fetal development. Topics covered include evolution, development, genetics and epigenetics, stem cells, metabolism, transport, immunology, pathology, pharmacology, cell and molecular biology, and developmental programming. The Editors welcome studies on implantation and the endometrium, comparative placentation, the uterine and umbilical circulations, the relationship between fetal and placental development, clinical aspects of altered placental development or function, the placental membranes, the influence of paternal factors on placental development or function, and the assessment of biomarkers of placental disorders.
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