Emerging trends in chitosan based colloidal drug delivery systems: A translational journey from research to practice

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED Carbohydrate Polymers Pub Date : 2025-04-17 DOI:10.1016/j.carbpol.2025.123604

Mahadev Manohar , Amitha Shetty , Cynthia Lizzie Lobo , Praneetha Jain , Srinivas Hebbar , Namdev Dhas , Kishori P. Sutar , Johan Sukeewandhi , Haribalan Perumalsamy , Sri Renukadevi Balusamy , Yahya F. Jamous , Akhilesh Dubey , Sally A. El-Zahaby

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Abstract

Chitosan, a natural polymer derived from chitin, has garnered significant interest in pharmaceutical and biomedical applications due to its distinctive properties, such as controlled drug release, mucoadhesive capabilities, in situ gelling property, enhancement of permeation, and efflux pump inhibitory effect. In this review, various types of chitosan based colloidal drug delivery systems such as vesicular, and particulate systems were discussed along with their role in pre-clinical biomedical applications. Some important clinical applications of chitosan-based drug delivery systems in treating major chronic diseases were also discussed. Using Chitosan in delivery of drugs and gene therapy had many beneficial outcomes, however, obtaining clinical acceptance and regulatory approval requires a careful approach for proving efficacy and safety. In order to present the current status of chitosan-based drug delivery systems, filled patents employing chitosan derivatives were also part of this review. This will help forward the use of chitosan-based drug delivery system from research to practice. Finally, the future prospects for chitosan-based delivery systems were discussed.

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基于壳聚糖的胶体给药系统的新趋势：从研究到实践的转化之旅

壳聚糖是一种从几丁质中提取的天然聚合物，由于其独特的特性，如药物释放控制、黏附能力、原位胶凝特性、增强渗透和抑制外排泵作用，在制药和生物医学领域得到了广泛的应用。本文综述了壳聚糖为基础的各种胶体给药系统，如囊泡系统和颗粒系统，及其在临床前生物医学应用中的作用。讨论了壳聚糖为基础的给药系统在重大慢性疾病治疗中的一些重要临床应用。使用壳聚糖进行药物输送和基因治疗有许多有益的结果，然而，获得临床接受和监管批准需要仔细的方法来证明有效性和安全性。为了介绍壳聚糖为基础的药物传递系统的现状，本文还对壳聚糖衍生物的填充专利进行了综述。这将有助于推动壳聚糖为基础的给药系统从研究到实践的应用。最后，展望了壳聚糖基递送系统的发展前景。

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.