Zhaobo Fu, Yanting Yu, Zeguo Fang, Qian Zhang, Dong Li
{"title":"Palladium-catalyzed aminocarbonylation of vinyl bromides with isocyanides for the synthesis of α,β-unsaturated amides","authors":"Zhaobo Fu, Yanting Yu, Zeguo Fang, Qian Zhang, Dong Li","doi":"10.1016/j.tet.2025.134668","DOIUrl":null,"url":null,"abstract":"<div><div>A palladium-catalyzed aminocarbonylation of vinyl bromides with isocyanides was developed, which provides the <em>α,β</em>-unsaturated amides in moderated to good yields. Both <em>α</em>- and <em>β</em>-bromoalkenes could be applied in this method and gave the corresponding linear or branched unsaturated amides with single configuration. It provided an efficient and facile method for the synthesis of <em>α,β</em>-unsaturated amides from readily available feedstocks.</div></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":"180 ","pages":"Article 134668"},"PeriodicalIF":2.2000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402025002248","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A palladium-catalyzed aminocarbonylation of vinyl bromides with isocyanides was developed, which provides the α,β-unsaturated amides in moderated to good yields. Both α- and β-bromoalkenes could be applied in this method and gave the corresponding linear or branched unsaturated amides with single configuration. It provided an efficient and facile method for the synthesis of α,β-unsaturated amides from readily available feedstocks.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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