Iodo-decarboxylation of Aliphatic Carboxylic Acids with PhI(OAc)2 and CHI3 under Ambient Conditions

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2025-04-21 DOI:10.1021/acs.orglett.5c00924

Kyoka Sakamoto, Kazunori Miyamoto, Masataka Kubota, Tadafumi Matsunaga, Shinichiro Kamino, Masanobu Uchiyama

引用次数: 0

Abstract

We have developed a mild and practical synthesis of primary, secondary and tertiary alkyl iodides by iododecarboxylation (decarboxylative iodination) of the corresponding carboxylic acids using (diacetoxyiodo)benzene and iodoform under ambient conditions. The method does not require heating or intense light irradiation and can be used to install iodine at the bridgehead position of strained cycloalkanes, as well as in a variety of alkanes with complex frameworks/functionalities.

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环境条件下脂肪族羧酸与PhI(OAc)2和CHI3的碘脱羧反应

在常温条件下，利用（二乙酰氧基碘）苯和碘仿对相应的羧酸进行碘十二脱羧（脱羧碘化），合成了一种温和实用的伯、仲、叔烷基碘化物。该方法不需要加热或强光照射，可用于在张力环烷烃的桥头堡位置安装碘，也可用于具有复杂框架/官能团的各种烷烃。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.