[Cefonicid toxicity. I. Effects on the reactivity of the specific immune system].

M Gariglio, A Franco, G Gribaudo, M G Martinotti, S Landolfo, G Cavallo
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Abstract

The degree of toxicity of the antibiotic Cefonicid on the cellular reactivity of the immune system was evaluated. The effects on some lymphokine (IL-2 and IFN-gamma) production and the degree of proliferation of splenic lymphocytes following mitogen stimulation have been considered. Our results show that Cefonicid does not impair the immune response, except at very high doses (500 micrograms/ml).

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(头孢尼西毒性。1 .对特异性免疫系统反应性的影响。
评价了头孢菌酸对免疫系统细胞反应性的毒性程度。有丝分裂原刺激对某些淋巴因子(IL-2和ifn - γ)的产生和脾淋巴细胞增殖程度的影响已被考虑。我们的研究结果表明,除了非常高的剂量(500微克/毫升)外,头孢菌酸不会损害免疫反应。
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