The effects of soy flour and N-nitrosobis (2-oxopropyl) amine on the pancreas of the hamster.

Abstract

Syrian golden hamsters fed diets of raw or heated soy flour for 16 months had an incidence (4%) of pancreatic neoplasms in both groups. Animals injected with N-nitrosobis (2-oxopropyl) amine (BOP) and fed heated soy flour for 15 months developed a high incidence (88%) of microscopic benign and malignant neoplasms, primarily of ductal origin. This was in marked contrast to a similar group of BOP-injected animals which had been fed raw soy flour and in which the incidence of pancreatic neoplasms was less than 10%.