Synthesis of 15O-labeled butanol via organoborane chemistry

G.W. Kabalka , R.M. Lambrecht , M. Sajjad , J.S. Fowler , S.A. Kunda , G.W. McCollum , R. MacGregor
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引用次数: 46

Abstract

Oxygen-15 labeled 1-butanol and 2-butanol were prepared by the reaction of O215O with tri-n-butylborane and tri-sec-butylborane in tetrahydrofuran. The reaction products were isolated and identified via reversed-phase high performance column chromatography and gas chromatography. Radiochemical yields of 50% (EOB) were obtained. The use of 15O-labeled butanol is suggested for cerebral blood flow measurements in conjunction with PET.

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有机硼烷化学法合成15o标记丁醇
在四氢呋喃中,O2 - 15O与三正丁基硼烷和三仲丁基硼烷反应制备了氧-15标记的1-丁醇和2-丁醇。反应产物通过反相高效柱层析和气相层析分离鉴定。放射化学产率为50% (EOB)。建议使用15o标记丁醇与PET一起用于脑血流量测量。
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