[The effect of various new GABAergics on motor and oral stereotypes with apomorphine in the rat].

Abstract

We have studied the effects of three new GABA-ergics (GABA-linoléamide (GL), GABA-palmitamide (GP) and GABA-steatamide (GS] on rat stereotypies with apomorphine (0,8 mg/kg i.p.). These GABA-ergics have been administered at a high dose (150 mg/kg i.p.) or a low one (10 or 3 mg/kg i.p.) and the following results have been observed: GL and GP at 150 mg/kg i.p. antagonised the locomotor activity and motor stereotypies. All these GABA-ergics (GL, GP and GS) potentiated the oral stereotypies (gnawing) when they are administered at low doses (10 or 3 mg/kg i.p.). GS at 3 mg/kg i.p. also potentiated the locomotor activity and motor stereotypies. These results were discussed in relation with some new data on the role of GABA in the basal ganglia and the nucleus accumbens.