Detection of pX proteins in human T-cell leukemia virus (HTLV)-infected cells by using antibody against peptide deduced from sequences of X-IV DNA of HTLV-I and Xc DNA of HTLV-II proviruses.

Gan Pub Date : 1984-09-01
M Miwa, K Shimotohno, H Hoshino, M Fujino, T Sugimura
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引用次数: 0

Abstract

A 41-kilodalton protein was detected in four human T-cell leukemia virus type I (HTLV-I)-infected cell lines, a 68-kilodalton glycoprotein in MT-2 cells, and a 38-kilodalton protein in an HTLV-II-infected cell line by using antibody against a synthetic dodecapeptide, a portion of the polypeptide deduced from the nucleotide sequence of the X regions of HTLVs.

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利用HTLV- i和HTLV- ii原病毒X-IV DNA序列和Xc DNA序列推导的肽抗体检测人t细胞白血病病毒(HTLV)感染细胞中的pX蛋白
利用抗体检测合成的十二肽(从htlv X区核苷酸序列推断出的一部分多肽),在4个人类t细胞白血病病毒I型(HTLV-I)感染细胞系中检测到41千道尔顿的糖蛋白,在MT-2细胞中检测到68千道尔顿的糖蛋白,在htlv - ii感染细胞系中检测到38千道尔顿的糖蛋白。
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