{"title":"Role of prostaglandins on growth hormone secretion: PGE2 a physiological stimulator.","authors":"F Dray, B Kouznetzova, D Harris, P Brazeau","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>PGE2 at 5 X 10(-8)M is a significant stimulator of GH release and seems to act at a step prior to the first signal for the inhibitory effect of SS. The amount of PGE2 released in the culture medium would appear, from what we have seen in our studies to date, to rule out any possibility that PGE2 is a GRF. However, the powerful role of PGE2 in the GH secretion process is evident. More detailed studies are needed, especially once a defined GRF becomes available. Investigations are currently in progress along these lines.</p>","PeriodicalId":75450,"journal":{"name":"Advances in prostaglandin and thromboxane research","volume":"8 ","pages":"1321-8"},"PeriodicalIF":0.0000,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in prostaglandin and thromboxane research","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
PGE2 at 5 X 10(-8)M is a significant stimulator of GH release and seems to act at a step prior to the first signal for the inhibitory effect of SS. The amount of PGE2 released in the culture medium would appear, from what we have seen in our studies to date, to rule out any possibility that PGE2 is a GRF. However, the powerful role of PGE2 in the GH secretion process is evident. More detailed studies are needed, especially once a defined GRF becomes available. Investigations are currently in progress along these lines.
5 X 10(-8)M的PGE2是生长激素释放的重要刺激物，似乎在SS抑制作用的第一个信号之前的一个步骤起作用。从我们迄今为止的研究中看到，培养基中释放的PGE2的量似乎排除了PGE2是GRF的任何可能性。然而，PGE2在生长激素分泌过程中的强大作用是显而易见的。需要进行更详细的研究，特别是一旦有了明确的粮食产量指标。目前正在沿着这些方向进行调查。
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