[Maternal-fetal alloimmunization in the Gm and InV system (inverse type of immunization in pregnancy)].

Abstract

Study of inverse alloimmunization, previously investigated in HLA-system, was continued by the investigation of maternal--foetal alloimmunization on Gm-system immunoglobulin allotypes (Steinberg-Speiser's phenomenon) in 105 cases of the newborn (cord blood) on antigen determinants of their mothers. The work includes investigation of Gm- and InV-system allotipie, using mothers' and their infants' blood by agglutination inhibition method (according to C. Ropartz and L. Rivat). Later on, using the same method, infants' sensitization to mothers' G-class immunoglobulin specificity was investigated. Allotypes bound to subclasses of G-class immunoglobulins, discrepancy in expression of certain specities of mothers and their infants, possible immaturity of some allotypes at birth and occurrence of immune response in both mother and infant are discussed in this paper. The occurrence we noted is a contribution to investigations of immunoglobulin genetics through Gm-system allotipie bound to protein primary structure.