[Neurological complications in drug dependence with special reference to the development of epileptic syndromes].

A Quattrini, A Paggi, A Ortenzi, R Silvestri, F Cianci, S Ardito, M Fronzoni, S Sgriccia, S Mancini
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Abstract

33 drug abusers were examined and all of them were addicts to several drugs and always to heroin. Neurological complications occurred rather frequently. One patient had subarachnoid hemorrhage and angiography showed no arteriovenous malformations nor other pathology. Polyneuropathy has been found in one case. 7 patients (21,2%) developed psychotic episodes. Epileptic attacks were found in 5 cases (15,1%). Latency between the onset of drug-abusing and occurrence of the attacks was found to be at least 1 year in two cases and 3 years in the other three. 4 cases suffered from partial complex seizures with secondary generalization and one patient had generalized tonic-clonic attacks. Fits occurred rarely in all cases; one patient had two episodes of partial status. Further research is required because there are few clinical reports in comparison with the experimental ones.

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[药物依赖的神经系统并发症,特别涉及癫痫综合征的发展]。
对33名药物滥用者进行了检查,他们都是几种药物的成瘾者,而且总是海洛因成瘾者。神经系统并发症的发生相当频繁。1例患者蛛网膜下腔出血,血管造影未见动静脉畸形及其他病理。一例发现多发性神经病。7例(21.2%)出现精神病发作。癫痫发作5例(15.1%)。发现两例发生药物滥用与发作之间的潜伏期至少为1年,其他三例为3年。4例为部分复杂发作,继发泛化,1例为全身性强直-阵挛发作。痉挛在所有病例中很少发生;一名患者有两次局部状态发作。由于临床报告与实验报告相比较少,需要进一步研究。
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