Domenico De Maio, Mariano Sesso, Alessandro Levi Minzi, Massimo A Caponeri, Carmen Mellado, Michele Bonicalzi
{"title":"Evaluation of the clinical efficacy of single daily doses of antidepressants","authors":"Domenico De Maio, Mariano Sesso, Alessandro Levi Minzi, Massimo A Caponeri, Carmen Mellado, Michele Bonicalzi","doi":"10.1016/0364-7722(81)90102-8","DOIUrl":null,"url":null,"abstract":"<div><p></p><ul><li><span>1.</span><span><p>1. In the light of the relationship between administration schedule and compliance, comparison data between divided dose regimen and one-time daily dosage of antidepressant drugs are reviewed in terms of therapeutic and pharmacokinetic equivalence.</p></span></li><li><span>2.</span><span><p>2. Divided (b.i.d.) and single (morning) doses of nomifensine (100–200 mg/die) were studied in patients affected with neurotic depression. Clinical results show that the two regimens do not differentiate as for antidepressant eff<span><math><mtext>i</mtext></math></span>cacy and safety.</p></span></li><li><span>3.</span><span><p>3. Nomifensine findings are compared to those obtained with amitriptyline (50–150 mg) given in three different schedules (three daily doses, single dose at morning, single dose at night).</p></span></li></ul></div>","PeriodicalId":20801,"journal":{"name":"Progress in neuro-psychopharmacology","volume":"4 6","pages":"Pages 607-612"},"PeriodicalIF":0.0000,"publicationDate":"1981-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0364-7722(81)90102-8","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in neuro-psychopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0364772281901028","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
Abstract
1.
1. In the light of the relationship between administration schedule and compliance, comparison data between divided dose regimen and one-time daily dosage of antidepressant drugs are reviewed in terms of therapeutic and pharmacokinetic equivalence.
2.
2. Divided (b.i.d.) and single (morning) doses of nomifensine (100–200 mg/die) were studied in patients affected with neurotic depression. Clinical results show that the two regimens do not differentiate as for antidepressant effcacy and safety.
3.
3. Nomifensine findings are compared to those obtained with amitriptyline (50–150 mg) given in three different schedules (three daily doses, single dose at morning, single dose at night).
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
