The effect of nifedipine and verapamil on rhythmic contractions of human isolated ureter.

Archives internationales de physiologie, de biochimie et de biophysique Pub Date : 1993-09-01 DOI:10.3109/13813459309003918

A Sahin, I Erdemli, M Bakkaloglu, A Ergen, I Basar, D Remzi

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引用次数: 35

Abstract

The effect of calcium antagonists nifedipine and verapamil on spontaneous rhythmic contractions of human isolated ureter obtained from donor subjects undergoing kidney transplantation was investigated in comparison with a nonsteroidal antiinflammatory drug indomethacin. Stop-times i.e. the time elapsing from application, were determined for each drug. The rank order of potency at 10(-8) and 10(-7) M concentrations of the drugs was: nifedipine > verapamil > or = indomethacin. However, no significant difference of the stop-times was observed at 10(-6) M concentration of the drugs tested. The rhythmic contractions were re-activated by PGF2 alpha after stoppage with indomethacin but not with nifedipine or verapamil. These results suggest that not only endogenous PG synthesis but also an influx of calcium from the extracellular space is responsible for the spontaneous rhythmic activity of human ureter. The beneficial effects of using calcium antagonists in the treatment of ureteric colic is discussed.

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硝苯地平与维拉帕米对人离体输尿管节律性收缩的影响。

研究了钙拮抗剂硝苯地平和维拉帕米对肾移植供体患者离体输尿管自发节律性收缩的影响，并与非甾体抗炎药吲哚美辛进行了比较。停止时间，即从应用的时间，被确定为每个药物。10(-8)、10(-7)M浓度下药物效价排序为:硝苯地平>维拉帕米>或=吲哚美辛。然而，在10(-6)M浓度下，停药时间无显著差异。在用吲哚美辛停止后，PGF2 α重新激活了节律性收缩，而硝苯地平或维拉帕米则没有。这些结果表明，不仅内源性PG合成，而且来自细胞外空间的钙流入也负责人类输尿管的自发节律活动。本文讨论了钙拮抗剂治疗输尿管绞痛的有益效果。

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Archives internationales de physiologie, de biochimie et de biophysique

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