Sex chromosome aneuploidy and aging

Mutation Research/DNAging Pub Date : 1995-10-01 DOI:10.1016/0921-8734(95)00016-Y

John F. Stone, Avery A. Sandberg

引用次数: 120

Abstract

Loss of an X chromosome in females and of the Y chromosome in males are phenomena associated with aging. X chromosome loss occurs in and may be limited to PHA stimulated peripheral lymphocytes. In males, the loss of the Y is most evident in bone marrow cells, but also occurs to a lesser extent in PHA stimulated peripheral lymphocytes. X chromosome loss is associated with premature centromere division leading to anaphase lag and elimination in micronuclei. The mechanism of Y chromosome loss has not been elucidated. No pathological consequence of either X or Y chromosome loss has been convincingly demonstrated. With the advent of FISH technology, measurement of sex chromosome aneuploidy may prove to be a convenient assay for cellular senecence and aging.

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性染色体非整倍体与衰老

女性失去X染色体，男性失去Y染色体是与衰老有关的现象。X染色体丢失发生在PHA刺激的外周淋巴细胞中，也可能仅限于这些细胞。在男性中，Y染色体的缺失在骨髓细胞中最为明显，但在PHA刺激的外周淋巴细胞中也较少发生。在微核中，X染色体丢失与着丝粒过早分裂导致后期滞后和消除有关。Y染色体丢失的机制尚未阐明。目前还没有令人信服的证据证明X染色体或Y染色体丢失的病理后果。随着FISH技术的出现，性染色体非整倍体的测量可能被证明是细胞衰老和衰老的一种方便的测定方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mutation Research/DNAging

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