In vitro study of cytotoxic activity of vinblastine in a free form and associated with nanoparticles.

M Simeonova, M Antcheva
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引用次数: 0

Abstract

The cytotoxic activities of unloaded polybutylcyanoacrylate nanoparticles (PBCN), free vinblastine, vinblastine-loaded nanoparticles (by incorporation and adsorption processes) and a mixture of vinblastine-free and unloaded PBCN were compared in vitro on human erythroleukemic K-562 cells. Enhanced cytotoxicity was observed when vinblastine was either adsorbed on PBCN or mixed with them rather than free. When vinblastine was incorporated into polymer matrix of nanoparticles, a lag period and postponed cytotoxic effect on K-562 cells were observed.

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游离形态长春花碱与纳米颗粒相关细胞毒活性的体外研究。
在体外比较了未负载的聚氰丙烯酸丁酯纳米颗粒(PBCN)、游离长春花碱、负载长春花碱纳米颗粒(通过掺入和吸附过程)以及不含长春花碱和负载的PBCN混合物对人红细胞K-562细胞的细胞毒活性。当长春花碱被吸附在PBCN上或与其混合而不是游离时,观察到细胞毒性增强。长春花碱掺入纳米颗粒聚合物基质后,对K-562细胞有滞后期和延迟的细胞毒性作用。
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