[Experience with peflacine in the treatment of osteomyelitis].

Abstract

Authors report on the treatment of 20 chronic osteomyelitis patients in whom direct antibiotic therapy was performed using the preparation Péflacine. The infected area was exposed in every case, the bony focus was excised and the wound was drained. During the operation, as an induction 800 mg Péflacine in slow drop infusion was given. Oral preparation (2 x 400 mg/die) followed, and was continued for 30 days. The secretion of the wounds ceased in every case, after 3 weeks the latest. In 2 cases mild gastrointestinal symptoms as side effects were observed. Relapse the first time occurred 5-7 months after ending the treatment in 3 patients. These were again explored and after the excision more thorough than before the secretion ceased. According their experience and in conformity with the literature the Péflacine is held an effective medicament in the treatment of the acute exacerbation of chronic osteomyelitis, together with the excision of the focus.