[Changes in serum lipid peroxide concentration in open heart surgery].

Ma zui xue za zhi = Anaesthesiologica Sinica Pub Date : 1993-06-01

P A Ye, S H Feng, C Y Lin

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Abstract

During open heart surgery, the release of oxygen free radicals as a result of ischemia and reperfusion often induces post-operative low cardiac output, arrhythmias or cardiac re-performance failure. Changes in serum lipid peroxide (LPO) concentrations were studied in 72 patients undergoing open heart surgery, to quantitate the rhythm of changes, and to seek for proper measures in myocardial protection. Blood samples were drawn before induction of anesthesia, just before aortic cross-clamping, 5 min after the release of aortic cross-clamping, immediately after rewarming to 35 degrees C, 30 min after cardiac performance, and at the end of the procedure. Fluorescent spectrophotometric method was used to detect the variation of LPO concentrations. The results showed that intraoperative serum LPO concentrations were significantly lower than pre-induction serum LPO concentrations (P < 0.01). It seems probable that methods of myocardial protection, hypothermia and hemodilution may induce lower concentrations of LPO. Serum LPO concentrations at the end of the procedure were smaller than those of the pre-induction concentrations (P > 0.05). This phenomena was caused by numerous factors that reduce serum LPO concentration.

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[心脏直视手术中血脂过氧化浓度的变化]。

在心脏直视手术中，由于缺血和再灌注导致的氧自由基释放常导致术后低心输出量、心律失常或心脏再功能衰竭。本文对72例心内直视手术患者血清过氧化脂(LPO)浓度的变化进行了研究，以定量测定其变化的节律，寻求适当的心肌保护措施。在麻醉诱导前、主动脉交叉夹紧前、主动脉交叉夹紧解除后5分钟、恢复至35℃后立即、心脏表现后30分钟和手术结束时抽取血样。采用荧光分光光度法检测LPO浓度变化。结果显示，术中血清LPO浓度显著低于诱导前血清LPO浓度(P < 0.01)。心肌保护、低温和血液稀释等方法可能导致LPO浓度降低。诱导结束时血清LPO浓度低于诱导前浓度(P > 0.05)。这种现象是由降低血清LPO浓度的多种因素引起的。

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Ma zui xue za zhi = Anaesthesiologica Sinica

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