Effects of female sex hormones on polyamine-oxidizing enzyme activities and polyamine concentrations in immature rat uterus and liver.

Experientia Pub Date : 1996-08-15 DOI:10.1007/BF01923991
O Dimitrov, V Pavlov, I Jotova
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引用次数: 10

Abstract

17 beta-estradiol (E2) and progesterone (P) treatment of immature female rats (10 micrograms/100 g body weight) respectively resulted in 1.38-fold (p < 0.02) and 1.42-fold (p < 0.02) increase in the uterine polyamine oxidase activity, and 2.45-fold (p < 0.001) and 1.43-fold (p < 0.02) increase in the uterine diamine oxidase activity, as compared to the controls. E2 caused a 5-fold (p < 0.05) and a 1.36-fold (p < 0.05) increase in putrescine and spermidine concentration respectively in rat uterus. Increases of 1.7-fold (p < 0.02) and 1.6-fold (p < 0.05) in putrescine and spermine concentration were determined in the P-treated uterus, as compared to the controls. The spermidine/spermine ratio, which is regarded as an index of growth rate, was higher in the E2-treated uterus and lower in the P-treated uterus than in the control uterus. No statistically significant hormonal effects were estimated in the immature liver. The data reported suggest the possibility of an involvement of polyamine-oxidizing enzymes in the modulation of polyamine concentrations in rat uterus by the female sex hormones.

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雌性荷尔蒙对未成熟大鼠子宫和肝脏中多胺氧化酶活性和多胺浓度的影响
与对照组相比,17 β-雌二醇(E2)和黄体酮(P)处理未成熟雌性大鼠(10 微克/100 克体重)分别导致子宫多胺氧化酶活性增加 1.38 倍(p < 0.02)和 1.42 倍(p < 0.02),子宫二胺氧化酶活性增加 2.45 倍(p < 0.001)和 1.43 倍(p < 0.02)。E2 可使大鼠子宫中的腐胺和精胺浓度分别增加 5 倍(p < 0.05)和 1.36 倍(p < 0.05)。与对照组相比,经 P 处理的子宫中腐胺和精胺浓度分别增加了 1.7 倍(p < 0.02)和 1.6 倍(p < 0.05)。与对照组相比,经 E2 处理的子宫中的精氨酸/精氨酸比率(被认为是生长速度的指标)较高,而经 P 处理的子宫中的精氨酸/精氨酸比率较低。据估计,激素对未成熟肝脏的影响没有统计学意义。报告的数据表明,多胺氧化酶可能参与了雌性激素对大鼠子宫中多胺浓度的调节。
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