Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity

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引用次数: 15

Abstract

The thioureido derivative of 4-aminoacetophenone aryl semicarbazone have been prepared. These derivatives have been characterised on the basis of different physicochemical evidences. The anti-HIV-1 (HTLV-IIIB) and -HIV-2 (ROD) activity and cytotoxicity of the compounds were tested. The compound VII and VIII showed maximum protection among the series.

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4-氨基苯乙酮芳基缩氨基脲的合成及其抗hiv活性研究
制备了4-氨基苯乙酮芳基氨基脲的硫脲衍生物。根据不同的物理化学证据对这些衍生物进行了表征。检测了化合物的抗hiv -1 (HTLV-IIIB)和-HIV-2 (ROD)活性和细胞毒性。其中化合物VII和VIII的保护作用最大。
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