Stereospecific synthesis and antiviral activities of beta-L-2',3'-dideoxy-5-chloropyrimidine nucleoside derivatives.

Nucleosides & nucleotides Pub Date : 1999-04-01 DOI:10.1080/15257779908041526

C Pierra, G Gosselin, J P Sommadossi, A Faraj, E De Clercq, J Balzarini, J L Imbach

引用次数: 1

Abstract

Several 5-chlorouracil and 5-chlorocytosine beta-L-dideoxynucleosides were stereospecifically synthesized and their activities against human immunodeficiency virus (HIV) and hepatitis B virus (HBV) were examined in cell culture.

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β - l -2′，3′-二脱氧-5-氯嘧啶核苷衍生物的立体特异性合成及其抗病毒活性。

立体特异性合成了几种5-氯尿嘧啶和5-氯胞嘧啶β - l -二脱氧核苷，并在细胞培养中检测了它们抗人类免疫缺陷病毒(HIV)和乙型肝炎病毒(HBV)的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nucleosides & nucleotides

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