The effects of calcium channel blocker and thyrotropin releasing hormone on acute necrotizing pancreatitis in rats.

Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie Pub Date : 1999-07-01 DOI:10.1007/s004330050132

E Alhan, U Küçüktülü, C Erçin, H Efe, S Al

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引用次数: 7

Abstract

The main purpose of this study was to investigate the influence of nimodipine, a calcium channel blocker (CCB) and thyroid-releasing hormone (TRH) on acute necrotizing pancreatitis (ANP) induced by glycodeoxycholic acid in rats. CCB decreased blood pressure in rats in the control and pancreatitis groups. TRH corrected this decrease. CCB alone had no effect on PO2 serum amylase activity, calcium concentration, liver transaminases, lactate dehydrogenase or the degree of pancreatic damage, except for the serum concentration of creatinine. CCB+TRH reduced the concentrations of serum urea and creatinine, the degree of pancreatic damage, and increased PO2 and serum calcium concentration. CCB and CCB+TRH had no effect on pancreatic myeloperoxidase activity. CCB alone had no effect on the course of ANP, but CCB+TRH had beneficial effects on the course of the ANP and various systems.

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钙通道阻滞剂和促甲状腺素释放激素对大鼠急性坏死性胰腺炎的影响。

本研究旨在探讨尼莫地平、钙通道阻滞剂(CCB)和甲状腺释放激素(TRH)对糖去氧胆酸致大鼠急性坏死性胰腺炎(ANP)的影响。CCB降低了对照组和胰腺炎组的血压。TRH纠正了这一减少。单独加CCB对PO2血清淀粉酶活性、钙浓度、肝转氨酶、乳酸脱氢酶及胰腺损伤程度均无影响，但对血清肌酐浓度有影响。CCB+TRH降低血清尿素和肌酐浓度，降低胰腺损伤程度，升高PO2和血钙浓度。CCB和CCB+TRH对胰腺髓过氧化物酶活性无影响。单独CCB对ANP病程无影响，但CCB+TRH对ANP病程及各系统均有有益影响。

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Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie

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