[An experimental study on promoting reconstruction of microcirculation of the ischemic skin flap with basic fibroblast growth factor].

Abstract

Objective: This study was to determine whether the basic fibroblast growth factor (bFGF) could promote reconstruction of microcirculation in the ischemic portion of a random skin flap.

Methods: Five methods were used in the experiment: measurement of the survival area of the skin flap; light and electron microscopic studies; immunohistochemical observation of the endothelial cell and microvessel image analysis technology (IAT).

Result: The survival area and microvessels in the skin flap were significantly increased in the treated group. The results indicate that bFGF can stimulate the proliferation and differentiation of endothelial cells in vivo and promote the microcirculation of the ischemic flap.

Conclusion: bFGF could promote reconstruction of microcirculation of the ischemic skin flap.